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It has been shown that the stiffening effect of cholesterol decreases with increasing unsaturation ( cm were found to be fully saturated and experiments on synthetic membranes found a negligible effect of cholesterol on the membranes bending rigidity when there are unsaturated molecules present

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Increased resting heart rate, by approximately 610 beats per minute, is a side effect of long-acting GLP-1RAs and heart rate should be monitored, particularly in patients with underlying cardiovascular disease [175]